Consolacion Y. Ragasa, Dinah L. Espineli, Esperanza Maribel G. Agoo, Ramon S. del Fierro
Aim: To investigate the chemical constituents of Cinnamomum cebuense, an endemic and critically endangered tree found only in Cebu, Philippines. Methods: The compounds were isolated by silica gel chromatography. The structures of the isolates were elucidated by NMR spectroscopy. Results: The dichloromethane (DCM) extract of the bark of C. cebuense afforded a new monoterpene natural product 1 and a new sesquiterpene 2, along with the known compounds, 4-hydroxy-3-methoxycinnamaldehyde (3), 4-allyl-2-methoxyphenol (4), α-terpineol (5) and humulene (6). The DCM extract of the leaves of C. cebuense yielded 6, β-caryophyllene (7), squalene (8), and a mixture of α-amyrin (9), β-amyrin (10) and bauerenol (11). The structures of 1-7 were elucidated by extensive 1D and 2D NMR spectroscopy, while the structures of 8-11 were identified by comparison of their 13C NMR data with those reported in the literature. Conclusion: The bark of C. cebuense afforded monoterpenes, sesquiterpenes and phenolics, while the leaves yielded sesquiterpenes and triterpenes. © 2013 China Pharmaceutical University.
Chemistry Department, Center for Natural Sciences and Ecological Research, De La Salle University, Manila 1004, Philippines; Biology Department, Center for Natural Sciences and Ecological Research, De La Salle University, Manila 1004, Philippines; Chemistry Department, University of San Carlos-Talamban Campus, 6000 Cebu City, Philippines
