Joo-Yeon Hwang, Xueling Sim, Ying Wu, Jun Liang, Yasuharu Tabara, Cheng Hu, Kazuo Hara, Claudia H.T. Tam, Qiuyin Cai, Qi Zhao, Sunha Jee, Fumihiko Takeuchi, Min Jin Go, Rick Twee Hee Ong, Takayoshi Ohkubo, Young Jin Kim, Rong Zhang, Toshimasa Yamauchi, Wing Yee So, Jirong Long, Dongfeng Gu, Nanette R. Lee, Soriul Kim, Tomohiro Katsuya, Ji Hee Oh, Jianjun Liu, Satoshi Umemura, Yeon-Jung Kim, Feng Jiang, Shiro Maeda, Juliana C.N. Chan, Wei Lu, James E. Hixson, Linda S. Adair, Keum Ji Jung, Toru Nabika, Jae-Bum Bae, Mi Hee Lee, Mark Seielstad, Terri L. Young, Yik Ying Teo, Yoshikuni Kita, Naoyuki Takashima, Haruhiko Osawa, So-Hyun Lee, Min-Ho Shin, Dong Hoon Shin, Bo Youl Choi, Jiajun Shi, Yu-Tang Gao, Yong-Bing Xiang, Wei Zheng, Norihiro Kato, Miwuk Yoon, Jiang He, Xiao Ou Shu, Ronald C.W. Ma, Takashi Kadowaki, Weiping Jia, Tetsuro Miki, Lu Qi, E. Shyong Tai, Karen L. Mohlke, Bok-Ghee Han, Yoon Shin Cho, Bong-Jo Kim
Fasting plasma glucose (FPG) has been recognized as an important indicator for the overall glycemic state preceding the onset of metabolic diseases. So far, most indentified genome-wide association loci for FPG were derived from populations with European ancestry, with a few exceptions. To extend a thorough catalog for FPG loci, we conducted meta-analyses of 13 genome-wide association studies in up to 24,740 nondiabetic subjects with East Asian ancestry. Follow-up replication analyses in up to an additional 21,345 participants identified three new FPG loci reaching genome-wide significance in or near PDK1-RAPGEF4, KANK1, and IGF1R. Our results could provide additional insight into the genetic variation implicated in fasting glucose regulation. © 2015 by the American Diabetes Association.
Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, South Korea; Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, United States; Centre for Molecular Epidemiology, National University of Singapore, Singapore, Singapore; Department of Genetics, University of North Carolina, Chapel Hill, NC, United States; Department of Nutrition, Harvard School of Public Health, Boston, MA, United States; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan; Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan; Department of Integrated Molecular Science on Metabolic Diseases, 22nd Century Medical and Research Center, University of Tokyo, Tokyo, Japan; Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong; Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN, United States; Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, United States; Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, South Korea; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore; Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, Japan; Department of Health Science, Shiga University of Medical Science, Shiga, Japan; State Key Laboratory of Cardiovascular Disease, Department of Epidemiology, National Center for Cardiovascular Diseases, Beijing, China; Population Genetics, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, China; Peking Union Medical College, Beijing, China; Office of Population Studies Foundation, University of San Carlos, Cebu City, Philippines; Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore; Department of Medical Science and Cardiorenal Medicine, University School of Medicine, Yokohama, Japan; Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China; Human Genetics Center, University of Texas School of Public Health, Houston, TX, United States; Department of Nutrition, University of North Carolina, Chapel Hill, NC, United States; Department of Functional Pathology, Shimane University School of Medicine, Izumo, Japan; Institute for Human Genetics, University of California, San Francisco, CA, United States; Center for Human Genetics, Duke University Medical Center, Durham, NC, United States; Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore; Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, Singapore; Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Toon, Japan; Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea; Department of Occupational and Environmental Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea; Department of Preventive Medicine, College of Medicine, Hanyang University, Seoul, South Korea; Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon, Japan; Department of Medicine, National University of Singapore, Singapore, Singapore; Duke-National University of Singapore Graduate Medical School, Singapore, Singapore; Department of Biomedical Science, Hallym University, Chuncheon, South Korea
