Wanqing Wen, Norihiro Kato, Joo-Yeon Hwang, Xingyi Guo, Yasuharu Tabara, Huaixing Li, Rajkumar Dorajoo, Xiaobo Yang, Fuu-Jen Tsai, Shengxu Li, Ying Wu, Tangchun Wu, Soriul Kim, Xiuqing Guo, Jun Liang, Dmitry Shungin, Linda S. Adair, Koichi Akiyama, Matthew Allison, Qiuyin Cai, Li-Ching Chang, Chien-Hsiun Chen, Yuan-Tsong Chen, Yoon Shin Cho, Bo Youl Choi, Yutang Gao, Min Jin Go, Dongfeng Gu, Bok-Ghee Han, Meian He, James E. Hixson, Yanling Hu, Tao Huang, Masato Isono, Keum Ji Jung, Daehee Kang, Young Jin Kim, Yoshikuni Kita, Juyoung Lee, Nanette R. Lee, Jeannette Lee, Yiqin Wang, Jian-Jun Liu, Jirong Long, Sanghoon Moon, Yasuyuki Nakamura, Masahiro Nakatochi, Keizo Ohnaka, Dabeeru Rao, Jiajun Shi, Jae Woong Sull, Aihua Tan, Hirotsugu Ueshima, Chen Wu, Yong-Bing Xiang, Ken Yamamoto, Jie Yao, Xingwang Ye, Mitsuhiro Yokota, Xiaomin Zhang, Yan Zheng, Lu Qi, Jerome I. Rotter, Sun Ha Jee, Dongxin Lin, Karen L. Mohlke, Jiang He, Zengnan Mo, Jer-Yuarn Wu, E. Shyong Tai, Xu Lin, Tetsuro Miki, Bong-Jo Kim, Fumihiko Takeuchi, Wei Zheng, Xiao-Ou Shu
Sixty genetic loci associated with abdominal obesity, measured by waist circumference (WC) and waist-hip ratio (WHR), have been previously identified, primarily from studies conducted in European-ancestry populations. We conducted a meta-analysis of associations of abdominal obesity with approximately 2.5 million single nucleotide polymorphisms (SNPs) among 53,052 (for WC) and 48,312 (for WHR) individuals of Asian descent, and replicated 33 selected SNPs among 3,762 to 17,110 additional individuals. We identified four novel loci near the EFEMP1, ADAMTSL3, CNPY2, and GNAS genes that were associated with WC after adjustment for body mass index (BMI); two loci near the NID2 and HLA-DRB5 genes associated with WHR after adjustment for BMI, and three loci near the CEP120, TSC22D2, and SLC22A2 genes associated with WC without adjustment for BMI. Functional enrichment analyses revealed enrichment of corticotropin-releasing hormone signaling, GNRH signaling, and/or CDK5 signaling pathways for those newly-identified loci. Our study provides additional insight on genetic contribution to abdominal obesity.
Department of Epidemiology, Vanderbilt University, School of Medicine, Nashville, 37203, TN, United States; Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University, Shanghai, China; Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Chinese Academy of Sciences, Shanghai, China; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore; Duke National University, Singapore Graduate Medical School, Singapore, Singapore; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore; National Center for Genome Medicine, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; School of Chinese Medicine, China Medical University, Taichung, Taiwan; Department of Medical Genetics, China Medical University Hospital, Taichung, Taiwan; Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan; Institute for Translational Genomics and Population Sciences, Department of Pediatrics and Medicine, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, United States; Department of Family and Preventive Medicine, University of California, San Diego, School of Medicine, San Diego, CA, United States; Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, South Korea; Department of Biomedical Science, Hallym University, Gangwon-do, South Korea; Department of Preventive Medicine, College of Medicine, Hanyang University, Seoul, South Korea; Department of Preventive Medicine, Seoul National University, College of Medicine, Seoul, South Korea; Institute for Health Promotion, Yonsei University, Seodaemun-Gu, Seoul, 120-749, South Korea; Eulji University, Seongnam City, Gyeonggi-do, South Korea; Center for Genomic Medicine, Kyoto University, Graduate School of Medicine, Kyoto, Japan; Department of Geriatric Medicine, Ehime University, Graduate School of Medicine, Ehime, Japan; Department of Health Science, Shiga University of Medical Science, Shiga, Japan; Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Shiga, Japan; Cardiovascular Epidemiology, Kyoto Women's University, Kyoto, Japan; Department of Nursing, Tsuruga University of Nursing, Tsuruga, Japan; Department of Clinical Sciences, Lund University Diabetes Center, Skane University Hospital, Malmö, 205 02, Sweden; Department of Public Health and Clinical Medicine, Unit of Medicine, Umea University, Umea, 901 87, Sweden; Department of Epidemiology, Tulane University, School of Public Health and Tropical Medicine, New Orleans, Louisiana, United States; Division of Biostatistics, Washington University, School of Medicine, St. Louis, MO, United States; Human Genetics Center, University of Texas, School of Public Health, Houston, TX, United States; Division of Population Genetics, Fuwai Hospital, Peking Union Medical College, Beijing, China; Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China; Institute of Urology and Nephrology, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China; Department of Chemotherapy, Affiliated Tumor Hospital, Guangxi Medical University, Nanning, Guangxi, 530021, China; Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi, 530021, China; Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China; Key Laboratory of Environment and Health, Ministry of Education, School of Public Health, Huazhong University of Science and Technology, Wuhan, Hubei, China; State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College, Beijing, China; Department of Nutrition, Harvard School of Public Health, Boston, 02115, MA, United States; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo, 1628655, Japan; Bioinformatics Section, Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Showa-ku, Nagoya, 466-8560, Japan; Department of Geriatric Medicine, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, 812-8582, Japan; Department of Medical Chemistry, Kurume University, School of Medicine, Kurume, Fukuoka, 830-0011, Japan; Department of Genome Science, Aichi-Gakuin University, School of Dentistry, Chikusa-ku, Nagoya, 464-8651, Japan; Department of Nutrition, University of North Carolina, Chapel Hill, 27599, NC, United States; Department of Genetics, University of North Carolina, Chapel Hill, 27599, NC, United States; Department of Endocrinology, Central Hospital of Xuzhou, Affiliated Hospital of Southeast University, Xuzhou, Jiangsu, China; Office of Population Studies Foundation Inc., University of San Carlos, Talamban, Cebu City, Philippines
