Linda S. Adair, Caroline H.D. Fall, Clive Osmond, Aryeh D. Stein, Reynaldo Martorell, Manuel Ramirez-Zea, Harshpal Singh Sachdev, Darren L. Dahly, Isabelita Bas, Shane A. Norris, Lisa Micklesfield, Pedro Hallal, Cesar G. Victora
Background Fast weight gain and linear growth in children in low-income and middle-income countries are associated with enhanced survival and improved cognitive development, but might increase risk of obesity and related adult cardiometabolic diseases. We investigated how linear growth and relative weight gain during infancy and childhood are related to health and human capital outcomes in young adults. Methods We used data from five prospective birth cohort studies from Brazil, Guatemala, India, the Philippines, and South Africa. We investigated body-mass index, systolic and diastolic blood pressure, plasma glucose concentration, height, years of attained schooling, and related categorical indicators of adverse outcomes in young adults. With linear and logistic regression models, we assessed how these outcomes relate to birthweight and to statistically independent measures representing linear growth and weight gain independent of linear growth (relative weight gain) in three age periods: 0-2 years, 2 years to mid-childhood, and mid-childhood to adulthood. Findings We obtained data for 8362 participants who had at least one adult outcome of interest. A higher birthweight was consistently associated with an adult body-mass index of greater than 25 kg/m2 (odds ratio 1·28, 95% CI 1·21-1·35) and a reduced likelihood of short adult stature (0·49, 0·44-0·54) and of not completing secondary school (0·82, 0·78-0·87). Faster linear growth was strongly associated with a reduced risk of short adult stature (age 2 years: 0·23, 0·20-0·52; mid-childhood: 0·39, 0·36-0·43) and of not completing secondary school (age 2 years: 0·74, 0·67-0·78; mid-childhood: 0·87, 0·83-0·92), but did raise the likelihood of overweight (age 2 years: 1·24, 1·17-1·31; mid-childhood: 1·12, 1·06-1·18) and elevated blood pressure (age 2 years: 1·12, 1·06-1·19; mid-childhood: 1·07, 1·01-1·13). Faster relative weight gain was associated with an increased risk of adult overweight (age 2 years: 1·51, 1·43-1·60; mid-childhood: 1·76, 1·69-1·91) and elevated blood pressure (age 2 years: 1·07, 1·01-1·13; mid-childhood: 1·22, 1·15-1·30). Linear growth and relative weight gain were not associated with dysglycaemia, but a higher birthweight was associated with decreased risk of the disorder (0·89, 0·81-0·98). Interpretation Interventions in countries of low and middle income to increase birthweight and linear growth during the first 2 years of life are likely to result in substantial gains in height and schooling and give some protection from adult chronic disease risk factors, with few adverse trade-offs. Funding Wellcome Trust and Bill & Melinda Gates Foundation. © 2013 Elsevier Ltd.
Department of Nutrition, Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516-2524, United States; MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, United Kingdom; Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, United States; Unit of Nutrition and Chronic Diseases, Institute of Nutrition of Central America and Panama, Guatemala City, Guatemala; Sitaram Bhartia Institute of Science and Research, New Delhi, India; Centre for Epidemiology and Biostatistics, University of Leeds, Leeds, United Kingdom; Office of Population Studies Foundation, University of San Carlos, Cebu, Philippines; Department of Pediatrics, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Universidade Federal de Pelotas, Pelotas, Brazil
